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A A Parsons Selected Research

tonabersat

4/2001Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.
7/2000The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan.
7/2000Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453.
3/2000SB-220453, a potential novel antimigraine agent, inhibits nitric oxide release following induction of cortical spreading depression in the anaesthetized cat.

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A A Parsons Research Topics

Disease

14Stroke (Strokes)
04/2002 - 03/2000
7Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
05/2002 - 01/2000
7Infarction (Infarctions)
03/2001 - 01/2000
5Ischemia
04/2001 - 03/2000
5Inflammation (Inflammations)
02/2001 - 03/2000
5Migraine Disorders (Migraine)
02/2001 - 01/2000
3Hyperalgesia
05/2001 - 09/2000
3Brain Ischemia (Cerebral Ischemia)
04/2001 - 01/2000
3Brain Injuries (Brain Injury)
03/2001 - 10/2000
1Narcolepsy
05/2002
1Neurodegenerative Diseases (Neurodegenerative Disease)
09/2001
1Neuralgia (Stump Neuralgia)
05/2001
1Ganglion Cysts (Ganglion)
04/2001
1Ischemic Stroke
03/2001
1Neurologic Manifestations (Neurological Manifestations)
02/2001
1Arthritis (Polyarthritis)
02/2001
1Hypersensitivity (Allergy)
01/2001
1Pain (Aches)
01/2001
1Hypertrophy
12/2000
1Craniocerebral Trauma (Head Injury)
11/2000
1Brain Edema (Cerebral Edema)
11/2000
1Closed Head Injuries
11/2000
1Wounds and Injuries (Trauma)
10/2000
1Necrosis
07/2000
1Neurogenic Inflammation
07/2000
1Traumatic Brain Injuries (Traumatic Brain Injury)
03/2000

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
12/2001 - 03/2000
4CytokinesIBA
09/2001 - 10/2000
4tonabersatIBA
04/2001 - 03/2000
4SB 239063IBA
03/2001 - 10/2000
4p38 Mitogen-Activated Protein KinasesIBA
03/2001 - 10/2000
3CarrageenanIBA
05/2001 - 09/2000
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2001 - 10/2000
3Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2001 - 03/2000
3Sumatriptan (Imigran)FDA LinkGeneric
01/2001 - 01/2000
2OrexinsIBA
05/2002 - 05/2001
2Messenger RNA (mRNA)IBA
05/2001 - 04/2001
2Morphine (MS Contin)FDA LinkGeneric
05/2001 - 09/2000
2Phosphotransferases (Kinase)IBA
03/2001 - 04/2000
2Glutamic Acid (Glutamate)FDA Link
07/2000 - 04/2000
2Interleukin-1 (Interleukin 1)IBA
07/2000 - 04/2000
1Orexin ReceptorsIBA
05/2002
1ApolipoproteinsIBA
04/2002
1Apolipoproteins E (ApoE)IBA
04/2002
1Amyloid (Amyloid Fibrils)IBA
12/2001
1Myelin Basic ProteinIBA
12/2001
1Neuroprotective AgentsIBA
09/2001
1CaspasesIBA
04/2001
1Caspase 3 (Caspase-3)IBA
04/2001
1Biological ProductsIBA
04/2001
1Lamotrigine (Lamictal)FDA LinkGeneric
04/2001
1Gabapentin (Neurontin)FDA LinkGeneric
04/2001
1triphenyltetrazoliumIBA
03/2001
1Dihydrotachysterol (AT 10)IBA
02/2001
1LipopolysaccharidesIBA
02/2001
1Endothelin-1 (Endothelin 1)IBA
12/2000
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
12/2000
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
12/2000
1SB 234551IBA
11/2000
1Endothelins (Endothelin)IBA
11/2000
1Endothelin A ReceptorIBA
11/2000
1(1S,2R,3S)- 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)- 4- methoxyphenyl)- 2,3- dihydro- 5- propoxy- 1H-Indene-2-carboxylic acidIBA
11/2000
1ChemokinesIBA
10/2000
1Cell Adhesion MoleculesIBA
10/2000
1Mitogen-Activated Protein KinasesIBA
09/2000
1Indomethacin (Indometacin)FDA LinkGeneric
09/2000
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
09/2000
1Inflammation MediatorsIBA
09/2000
12- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
09/2000
1Nerve Growth Factor (NGF)IBA
09/2000
1SB 221420-AIBA
08/2000
1NF-kappa B (NF-kB)IBA
07/2000
1BenzopyransIBA
07/2000
1ConvulsantsIBA
07/2000
1Mitogen-Activated Protein Kinase 11IBA
04/2000
1Interleukin-6 (Interleukin 6)IBA
03/2000
1InterleukinsIBA
03/2000
1Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
03/2000
1NAD (NADH)IBA
01/2000
1Insulin (Novolin)FDA Link
01/2000
1Glucose (Dextrose)FDA LinkGeneric
01/2000
1Therapeutic UsesIBA
01/2000
1ChloraloseIBA
01/2000

Therapy/Procedure

2Therapeutics
12/2000 - 01/2000
1Ligation
01/2001
1Sutures (Suture)
11/2000
1Investigational Therapies (Experimental Therapy)
01/2000
1Anesthesia
01/2000